CareDx

AlloSeq® Tx17 / Tx9

AlloSeq Tx is an innovative NGS-based HLA genotyping solution that uses capture hybridisation technology to determine the genetic match between a patient awaiting transplantation and the potential donor.

AlloSeq Tx goes beyond traditional transplant loci to consider more transplant-related genes and help you identify the best genetic match.

• Hybridization Capture Technology:
  • no risk of sub-optimal or inefficient amplification
  • significantly reduced probability of dropout
  • Constant allelic balance
  • No restriction due to primers recognition sitexes

• Early indexing: Reduction in pipetting steps and consumables
• Low DNA requirement and tolerance of low gDNA quality
• Rapid data processing using AlloSeq Assign software
• Additional loci can be typed without impacting workflow

AlloSeq® HCT

AlloSeq HCT is a comprehensive, targeted NGS-based solution for the relative quantification of genetic chimerism in a DNA sample from a haematopoietic stem cell transplant patient:

• Low handling time: library preparation in 3 hours

• Distinction of the contribution of up to 3 genomes (recipient + 2 donors) within a sample

• High sensitivity for early indication of relapses
• From extracted sample to results report in less than 24 hours
• Automated analysis

AlloSeq® cfDNA

AlloSeq cfDNA is a state-of-the-art solution for the detection and measurement of donor-derived cfDNA in the follow-up of solid organ transplants.

The AlloSeq cfDNA assay enables the measurement of dd-cfDNA by NGS from a blood sample and the relative quantification of circulating free donor-derived DNA (cfDNA) in a circulating free DNA sample from a transplant recipient.

• Non-invasive tool for monitoring organ transplantation
• High sensitivity for early indication of graft organ damage
• Low quantity of cDNA required

• Short handling time: library preparation in 1.5 hours
• From extracted sample to results report in less than 24 hours
• Automated analysis